On the basis of the molecular function of C11orf53, we renamed it as “POU Class 2 Homeobox Associating Factor 2” (POU2AF2). Depletion of C11orf53 reduced enhancer H3K27ac levels and chromatin accessibility, resulting in a reduction of POU2F3-dependent gene expression.
Mechanistically, C11orf53 directly interacts with POU2F3 and is recruited to chromatin by POU2F3. Here, we have identified a previously uncharacterized protein, C11orf53, which is coexpressed with POU2F3 in both SCLC cell lines and patient samples. The POU class 2 homeobox 3 (POU2F3) is a master regulator of tuft cell identity and defines the SCLC-P subtype that lacks the neuroendocrine markers. The most commonly used bridges are obfs4.Small cell lung cancer (SCLC), accounting for around 13% of all lung cancers, often results in rapid tumor growth, early metastasis, and acquired therapeutic resistance. Snowflake sends your traffic through WebRTC, a peer-to-peer protocol with built-in NAT punching. meek_lite makes it look like you are using a Microsoft web site. Meek transports make it look like you are browsing a major web site instead of using Tor. Obfs4 bridges makes Tor traffic look random, and also prevents censors from finding bridges by Internet scanning. Obfs3 and scrablesuit bridges are deprecated. Vanilla bridges do not use pluggable transport at all, but like other bridges, they use servers that are not listed publicly. They use different methods of circumventing censorship. Several types of pluggable transports can be used with bridges: obfs4, obfs3, scramblesuit, meek_lite, and snowflake. Pluggable transport is designed to transform ordinary Tor traffic to a special one, which is impossible or very difficult to block. But you can bypass blockage by using bridges with pluggable transport. Also, in some countries, ordinary Tor entry servers are blocked, and/or Tor network is blocked by DPI. Using bridges in combination with pluggable transports helps to disguise the fact that you are using Tor, but may slow down the connection compared to using ordinary Tor servers. Like ordinary Tor servers, bridges are run by volunteers unlike ordinary servers, however, they are not listed publicly, so an adversary cannot identify them easily. Tor Bridge is the first server in the common chain of Tor servers, which is required to protect your privacy. Ordinary Tor connection Tor with Bridge connection
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